A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Impact of SARS-CoV-2 variants on mobility and air pollution in the United KingdomArticle Published on 2022-12-102022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] activity affecting Algorithm Alpha baseline baseline level baseline levels contagiousness COVID-19 COVID-19 case death Delta event Government Immunity Impact Increases measure NO(2) normality Pollution prevalent Public public health reduced remained Result returned SARS-CoV-2 variant significant increase significantly social contact Spread Traffic Traffic. United Kingdom variant variants virus wildtype [DOI] 10.1016/j.scitotenv.2022.158279 PMC 바로가기
Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다Article Published on 2022-12-012022-09-11 Journal: Annals of Medicine [Category] 바이오마커, 진단, [키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured [DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article
COVAD survey 2 long-term outcomes: unmet need and protocolArticle Published on 2022-12-012022-11-15 Journal: Rheumatology International [Category] 치료제, [키워드] adverse event antiviral drug approach approved Autoimmune diseases baseline booster doses cohorts COVID-19 COVID-19 infection COVID-19 vaccine disease Effect effort groups help Heterologous immune modulation Immunity IMPROVE long-term adverse effects pandemic protocol reduce registries risk syndrome synergistic Tolerability translation unmet need vaccination vaccination. Vaccine while [DOI] 10.1007/s00296-022-05157-6 PMC 바로가기
Combination therapy with remdesivir and immunomodulators improves respiratory status in COVID-19: A retrospective studyArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval Analysis Baricitinib baseline benefit body mass index combination therapy Concomitant contributed control group coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Day Diabetes Mellitus examined faster greater hazard ratio immunomodulator immunomodulators IMPROVE in both group independent investigated median outcome Oxygen administration Patient patients Prognostic factors Remdesivir respiratory recovery retrospective Retrospective study severity single-center study standard treatment supplemental oxygen survival synergistic therapy Tocilizumab tocilizumab. treated two group [DOI] 10.1002/jmv.28037 PMC 바로가기
Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trialArticle Published on 2022-11-032022-11-16 Journal: Journal of Translational Medicine [Category] 비임상, [키워드] 1:1 Administered administration adverse event age Analysis animal model Anti-inflammatory assigned baseline Borg change changes in Chronic diseases clinical trial clinically COVID COVID pneumonia COVID-19 defined Diagnosis discharged double-blind Dyspnea Effect effective Efficacy Endpoint enrolled evaluated female female gender FEV first symptom FVC impairment increase in indicated Infection initial LLC lung damage Lung fibrosis Lung function Lungs mMRC moderate NCT04527354 offer past medical history Patient patients pharmacological treatment Placebo placebo group placebo-controlled clinical trial placebo-controlled trial Post-COVID rehabilitation predicted Prevent Primary outcome proportion pulmonary dysfunction pulmonary fibrosis Pulmonary function questionnaire Randomized Randomly reduction in Registered rehabilitation risk factor Russia SARS-CoV-2 secondary shown significant decrease significant difference stratified Support Symptoms Tolerability Treamid. Treatment Trial was done women [DOI] 10.1186/s12967-022-03660-9 PMC 바로가기
Humoral response and safety of BNT162b2 mRNA vaccine in children with rheumatic diseasesArticle Published on 2022-11-022022-11-15 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, [키워드] acute respiratory syndrome Administered Anti-RBD IgG antibody Antibody Response approval baseline biologic BNT162b2 mRNA BNT162b2 mRNA vaccine children Cohort cohort of patient Combined therapy coronavirus coronavirus disease COVID-19 disease Disease activity domain dose dose regimen effective elevated evaluated humoral Humoral response IgG antibody immunogenicity immunomodulatory IQR Local median mRNA vaccine of BNT162b2 paediatric rheumatic disease. pandemic Patient RBD receiving rheumatic disease safety profile SARS-CoV-2 second dose significantly lower Spike protein study period systemic side effect titre treated Treatment Vaccine were measured [DOI] 10.1093/rheumatology/keac140 PMC 바로가기
Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trialArticle Published on 2022-11-022022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] approved assessment baseline Blood Cardiology case sery chronic fatigue syndrome chronic inflammation clinical clinical trial cognitive collected common COVID-19 defined domain double-blind dysfunction Effect effective Efficacy endothelial function Ethics evaluate fatigue healthy subject hyperbaric oxygen hypothese immunology IMPROVE Inconclusive independent individual initial institutional review board Long malaise mechanism monitoring board oxygen Oxygen therapy pandemic Patient peer-reviewed performed physical placebo-controlled placebo-controlled clinical trial positive Potential treatment product protocol Quality of life Questionnaires randomised rehabilitation medicine respiratory medicine (see thoracic medicine) secondary endpoint suggested survey Swedish Symptom syndrome the primary endpoint Treatment Trial VASCULAR MEDICINE. [DOI] 10.1136/bmjopen-2022-061870 PMC 바로가기
Serum neurofilament light chain levels in Covid-19 patients without major neurological manifestationsArticle Published on 2022-11-012022-11-15 Journal: Journal of Neurology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] absence Admission baseline Biomarker Blood Brescia C-reactive protein change controls correlated COVID-19 CRP D-dimer disease severity evaluated Evidence excluded explained fibrinogen healthy controls Hospital stay Hospitalized hypoxic Increased longitudinal measure Neuroaxonal damage neurofilament Neurofilament light chain (NFL) neurological manifestation neurological manifestations neurotoxic PaO2/FiO2 ratio parameters Patient patients plasma promote reported respiratory respiratory impairment SARS-CoV-2 scale serum serum creatinine serum CRP Serum level serum sample serum. significantly Simoa systemic inflammation Variation were measured White blood cell with mild disease [DOI] 10.1007/s00415-022-11233-5 PMC 바로가기
Immunological responses following the third dose of the BNT162b2 SARS-CoV-2 vaccine among Japanese healthcare workersArticle Published on 2022-11-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 진단, [키워드] age alcohol all age groups anti-RBD antibody antibody level antibody levels Antibody Response Antibody titer Asian baseline binding domain BNT162b2 BNT162b2 mRNA BNT162b2 vaccine Boosted vaccination booster dose booster vaccination conducted COVID-19 COVID-19 vaccine dose eight elevated Ethnic groups group healthcare worker Healthcare workers healthcare workers. healthy IgG information investigated Japan Japanese median median titer of BNT162b2 participant Prevent provided RBD response SARS-CoV-2 vaccine second dose serum shown significant increase the vaccine university vaccination Welfare [DOI] 10.1016/j.jiac.2022.07.006 PMC 바로가기